Journal
TRENDS IN NEUROSCIENCES
Volume 31, Issue 6, Pages 273-278Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.02.009
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCRR NIH HHS [RR017699, P20 RR017699] Funding Source: Medline
- NINDS NIH HHS [NS61290, R15 NS061290, NS29173, R01 NS029173] Funding Source: Medline
Ask authors/readers for more resources
Abnormal neuronal signaling caused by metabolic changes characterizes several neurological disorders, and in some instances metabolic interventions provide therapeutic benefits. Indeed, altering metabolism either by fasting or by maintaining a low-carbohydrate (ketogenic) diet might reduce epileptic seizures and offer neuroprotection in part because the diet increases mitochondrial biogenesis and brain energy levels. Here we focus on a novel hypothesis that a ketogenic diet-induced change in energy metabolism increases levels of ATP and adenosine, purines that are critically involved in neuron-glia interactions, neuromodulation and synaptic plasticity. Enhancing brain bioenergetics (ATP) and increasing levels of adenosine, an endogenous anticonvulsant and neuroprotective molecule, might help with understanding and treating a variety of neurological disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available