Journal
TRENDS IN MOLECULAR MEDICINE
Volume 20, Issue 11, Pages 623-631Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.09.002
Keywords
long non-coding RNA; lncRNA; lincRNA; innate immunity; gene expression; epigenetics
Funding
- American Heart Association [14POST18930001]
- National Institute of Health [AI067497]
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All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
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