Journal
TRENDS IN MOLECULAR MEDICINE
Volume 20, Issue 12, Pages 716-725Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.10.006
Keywords
miRNAs; myocardial infarction; biomarker; therapeutic targets; personalized medicine
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miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.
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