Journal
TRENDS IN MOLECULAR MEDICINE
Volume 20, Issue 5, Pages 239-241Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.01.009
Keywords
lysosome; membrane; permeabilization; cathepsin; cancer; target
Ask authors/readers for more resources
Lysosomes are organelles with an acidic lumen containing hydrolases, whose role is to break down macromolecules into their subunits. Cathepsins, which are lysosomal proteases, have important roles in cancer. Enhanced cathepsin activity out of the cell is linked to tumor growth, whereas such activity inside the cell is linked to tumor growth inhibition. Recently published studies on the opposing roles of cathepsin in cancer have investigated their potential as biochemical and nanotechnological therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available