Journal
TRENDS IN MOLECULAR MEDICINE
Volume 20, Issue 1, Pages 36-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.10.005
Keywords
miRNA; smoking; cancer; epigenetics; signaling; diagnostic
Funding
- National Institutes of Health [TMEN U54 CA163120, EDRN UO1 CA111294, RO1 CA131944, RO1 CA133774, SPORE P50 CA127297, RO3 CA167342, RO1 CA78590]
- VA Career Development Award
- NATIONAL CANCER INSTITUTE [R01CA131944, P50CA127297, U01CA111294, R03CA167342, R01CA078590, U54CA163120, R01CA133774] Funding Source: NIH RePORTER
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MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.
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