Journal
TRENDS IN MOLECULAR MEDICINE
Volume 20, Issue 5, Pages 271-281Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.12.001
Keywords
atherosclerosis; inflammation; liposome; nanomedicine
Funding
- Netherlands Organisation for Scientific Research (NWO) [91712303]
- Deutsche Forschungsgemeinschaft (DFG) [S087613-1, S0876/6-1, FOR809, SFB914, TP B08]
- LMUexcellent program
- Else Kroner Fresenius Stiftung
Ask authors/readers for more resources
Atherosclerosis is a chronic inflammatory disease of the arterial wall that arises from an imbalanced lipid metabolism and a maladaptive inflammatory response. Despite intensive research on mechanisms underlying atherosclerotic lesion formation and progression during the past decade, translation of this knowledge into the clinic is scarce. Although developments have primarily been made in the area of antitumor therapy, recent advances have shown the potential of nanomedicine-based treatment strategies for atherosclerosis. Here we describe the features of currently available nanomedical formulations that have been optimized for atherosclerosis treatment, and we further describe how they can be instructed to target inflammatory processes in the arterial wall. Despite their limitations, nanomedical applications might hold promise for personalized medicine, and further efforts are needed to improve atherosclerosis-specific targeting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available