Journal
TRENDS IN MOLECULAR MEDICINE
Volume 19, Issue 7, Pages 410-417Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.04.001
Keywords
collagen VI; cancer; angiogenesis; inflammation; chemotherapy resistance; therapeutic target
Funding
- Fondazione Cariparo
- University of Padova
Ask authors/readers for more resources
Collagen VI is a widely distributed extracellular matrix protein highly expressed in a variety of cancers that favors tumor growth and progression. A growing number of studies indicate that collagen VI directly affects malignant cells by acting on the Akt-GSK-3 beta-beta-catenin-TCF/LEF axis, enhancing the production of protumorigenic factors and inducing epithelial-mesenchymal transition. Moreover, it affects the tumor microenvironment by increasing the recruitment of macrophages and endothelial cells, thus promoting tumor inflammation and angiogenesis. Furthermore, collagen VI promotes chemotherapy resistance and can be regarded as a potential biomarker for cancer diagnosis. Collectively, these findings strongly support a role for collagen VI as an important regulator in tumors and provide new targets for cancer therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available