Journal
TRENDS IN MOLECULAR MEDICINE
Volume 19, Issue 2, Pages 117-124Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.11.004
Keywords
breast cancer; TRP; proliferation; migration; estrogen receptors; cancer biomarkers
Funding
- Region Picardie
- Ministere de l'Enseignement Superieur et de la Recherche, France
- La Ligue Nationale contre le cancer
- SEPTENTRION
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Breast cancer is the most frequently occurring cancer in women and has the highest rate of mortality. Ion channels such as the transient receptor potential (TRP) channels could play a critical role in the development and progression of cancer. Although these channels are frequently and abundantly expressed in many tumors, their expression, activity, and roles in the context of breast cancer remain poorly understood. This review summarizes our current knowledge regarding TRP channels expressed in human breast tissue, primary human breast epithelial cells, and cell lines, the functional role of TRP channels during breast cancer cell growth and migration, as well as their relationship with clinical and pathological features.
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