4.6 Editorial Material

TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates

Journal

TRENDS IN MOLECULAR MEDICINE
Volume 18, Issue 1, Pages 4-5

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2011.09.001

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Funding

  1. Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom

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Phagocytosis is used not only for immune defense but may also be used to obtain nutrients, as observed when tumor cells feed upon neighboring cells during tumor cell cannibalism. The TM9 protein TM9SF4, important in canonical phagocytosis, is involved in this cannibalism by metastatic cells and may represent a novel therapeutic target.

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