Journal
TRENDS IN MOLECULAR MEDICINE
Volume 18, Issue 12, Pages 732-741Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.09.009
Keywords
granzyme B; extracellular matrix; wound healing; aging; skin; inflammation
Funding
- Canadian Institutes of Health Research (CIHR)
- CIHR Skin Research Training Centre
- Natural Sciences and Engineering Research Council of Canada
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Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B is observed during prolonged inflammation and is implicated in the pathogenesis of several chronic inflammatory diseases. Although its role in cytotoxic lymphocyte-mediated apoptosis is well established, granzyme B can also degrade extracellular matrix proteins and alter inflammation if present in the extracellular milieu. The present review focuses on the emerging evidence for the involvement of granzyme B in chronic inflammation, impaired wound healing, and age-related skin fragility.
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