Journal
TRENDS IN MOLECULAR MEDICINE
Volume 18, Issue 6, Pages 328-336Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.04.007
Keywords
environmental enteropathy; tropical enteropathy; malnutrition; stunting; oral vaccine failure; mucosal immunity; fecal-oral contamination
Funding
- NIAID NIH HHS [T32 AI055432, R01 AI043596] Funding Source: Medline
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Environmental enteropathy (also called tropical enteropathy) is a subclinical condition caused by constant fecal oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Although these histological changes were discovered decades ago, the clinical impact of environmental enteropathy is just starting to be recognized. The failure of nutritional interventions and oral vaccines in the developing world may be attributed to environmental enteropathy, as the intestinal absorptive and immunologic functions are significantly deranged. Here we review the existing literature and examine potential mechanisms of pathogenesis for this poorly understood condition.
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