Journal
TRENDS IN MOLECULAR MEDICINE
Volume 18, Issue 6, Pages 337-347Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.04.003
Keywords
-
Funding
- Research Councils UK
- Cancer Research UK [C20953/A10270]
- American Cancer Society [RSG-07-157-01-CNE]
- Royal Society
- Anonymous Trust
- Tenovus Scotland
- Biotechnology and Biological Sciences Research Council [BB/J007498/1] Funding Source: researchfish
- Cancer Research UK [10270] Funding Source: researchfish
- BBSRC [BB/J007498/1] Funding Source: UKRI
Ask authors/readers for more resources
Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following the discovery that sulforaphane, an isothiocyanate from broccoli, potently induces mammalian cytoprotective proteins through the Keap1-Nrf2-ARE pathway. In parallel with the advances in understanding the molecular regulation of this pathway and its critical role in protection against electrophiles and oxidants, there have been increased efforts toward translating this knowledge to improve human health and combat disease. This review focuses on the animal studies demonstrating the beneficial effects of glucosinolates and isothiocyanates in models of carcinogenesis, and cardiovascular and neurological diseases, as well as on the intervention studies of their safety, pharmacokinetics, and efficacy in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available