Journal
TRENDS IN MOLECULAR MEDICINE
Volume 18, Issue 9, Pages 544-554Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.07.001
Keywords
netrin-1; DCC; UNC-5H; neuronal guidance; dependence receptors; cell survival; enteric nervous system; colorectal cancer
Funding
- Faculty of Health, Engineering and Science Postgraduate Research Scholarship at Victoria University
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Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer.
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