Journal
TRENDS IN MOLECULAR MEDICINE
Volume 17, Issue 9, Pages 475-484Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2011.05.001
Keywords
-
Funding
- Netherlands Heart Foundation
- EU [PIAP-GA-2008-230675]
- ZonMW [114000101]
- Netherlands Institute of Regenerative Medicine
- Netherlands Proteomics Consortium [050-040-250]
- Netherlands Organization for Scientific Research (NWO)
- Marie Curie Cofund Action
Ask authors/readers for more resources
Recent advances in pluripotent stem cell biology now make it possible to generate human cardiomyocytes in vitro from both healthy individuals and from patients with cardiac abnormalities. This offers unprecedented opportunities to study cardiac disease development 'in a dish' and establish novel platforms for drug discovery, either to prevent disease progression or to reverse it. In this review paper, we discuss some of the genetic diseases that affect the heart and illustrate how these new paradigms could assist our understanding of cardiac pathogenesis and aid in drug discovery. In particular, we highlight the limitations of other commonly used model systems in predicting the consequences of drug exposure on the human heart.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available