Journal
TRENDS IN MOLECULAR MEDICINE
Volume 16, Issue 10, Pages 469-477Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.07.008
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Funding
- Canadian Institute for Health Research, Natural Sciences and Engineering Research Council of Canada
- Fonds de la recherche en sante du Quebec
- Alzheimer Society of Canada
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Converging evidence from clinical and pathological studies indicate the presence of important relationships between the ongoing deterioration of brain lipid homeostasis, vascular changes and the pathophysiology of sporadic Alzheimer's disease (AD). These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia. Moreover, recent clinical findings lend support to the notion that progressive deterioration of cholesterol homeostasis in AD is a central player in the disease pathophysiology and is, therefore, a potential therapeutic target for disease prevention.
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