Journal
TRENDS IN MOLECULAR MEDICINE
Volume 15, Issue 2, Pages 50-58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2008.12.004
Keywords
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Funding
- 'Fundacao para Ciencia e Tecnologia', Portugal [POCTI/BIA-BCM/56829/2004, POCTI/SAU-MNO/56066/2004, POCTI/SAU-MNO/56066/2007]
- European Commission's Sixth Framework Programme, Xenome [LSHB-CT-2006-037377]
- GEMI fund (Linde Health care)
- National Institutes of Health [HL77721, HL58688]
- Julie Henry Fund of the Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
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Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase). Over the past few years it has become apparent that these 'arms' of the HO-1 system can act protectively in a variety of experimental models of disease; there is also evidence that HO-1 and bilirubin have protective actions in humans. Here, we present a model for the beneficial actions of the products of heme degradation, and we discuss the potential clinical applications of enhancing the HO-1 system.
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