Journal
TRENDS IN MOLECULAR MEDICINE
Volume 15, Issue 7, Pages 303-312Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2009.05.003
Keywords
-
Funding
- Ministry for Health, Welfare and Family Affairs [BGC0800824]
- Ministry of Education, Science and Technology [TNC0400823]
- BMBF [01KI 0703]
Ask authors/readers for more resources
Regulated proteolysis of cellular factors is pivotal to tissue development and homeostasis, whereas uncontrolled proteolytic activity is linked to disease. Type II transmembrane serine proteases (TTSPs) are expressed at the cell surface and are thus ideally located to regulate cell-cell and cell-matrix interactions. Increasing evidence demonstrates that aberrant expression of TTSPs is a hallmark of several cancers and recent studies have defined molecular mechanisms underlying TTSP-promoted carcinogenesis. In addition, new findings suggest that influenza and other respiratory viruses could exploit TTSPs to promote their spread, making these proteases potential targets for intervention in cancer and viral infections. Here, we review the role of TTSPs in tumorigenesis and viral infection and discuss potential approaches to therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available