Journal
TRENDS IN MOLECULAR MEDICINE
Volume 15, Issue 4, Pages 159-168Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2009.02.002
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Funding
- National Institutes of Health (NIH) [NICHD R01 HD056034, R03 HD051512, NICHD U54 HD029990, Project 5]
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Recent studies have shown that male reproductive function is modulated via the mitogen-activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male reproductive processes, including spermatogenesis, sperm maturation and activation, capacitation and acrosome reaction, before fertilization of the oocyte. In this review, we discuss the latest findings in this rapidly developing field regarding the role of MAPK in male reproduction in animal models and in human spermatozoa in vitro. This research will facilitate the design of future studies in humans, although much work is needed before this information can be used to manage male infertility and environmental toxicant-induced testicular injury in men, such as blood-testis-barrier disruption.
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