Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 7, Pages 417-424Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.03.008
Keywords
bacteria; persisters; pathogens; infection; antibiotic tolerance
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Funding
- Junior Research Fellowship from Imperial College London
- MRC [MR/J006874/1] Funding Source: UKRI
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Persisters are multidrug-tolerant bacteria that could account for the relapse of infections. For a long time, persisters have been assumed to be nonreplicating dormant bacteria, but the growth status of these recalcitrant cells is still debated. Toxin antitoxin (TA) modules have an important role in the formation of persisters and several studies show that they can form in response to different triggers. These findings, together with the invention of new tools to study persisters, could have important implications for the development of novel therapeutics to eradicate persisting subpopulations.
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