Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 12, Pages 686-696Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.09.003
Keywords
Klebsiella pneumoniae carbapenemase; carbapenem-resistant; ST258
Categories
Funding
- National Institutes of Health (NIH) [1R01AI090155]
- Intramural Research Program of the NIAID, NIH
- Public Health Service [R01AI072219, R01AI063517]
- Cleveland Department of Veterans Affairs
- Veterans Affairs Merit Review Program
- Geriatric Research Education and Clinical Center [VISN 10]
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Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of bla(KPC) involves both horizontal transfer of bla(KPC) genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.
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