Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 3, Pages 128-137Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.01.003
Keywords
intracellular bacteria; vacuolar rupture; membrane trafficking; host cell death
Categories
Funding
- European Research Council (ERC StG) [261166]
- Pasteur Foundation
- European Research Council (ERC) [261166] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens rupture their endocytic vacuoles as well as the mechanisms used to accomplish this task by bacterial species for which host cytoplasmic localization has only recently been identified. We also discuss the consequences for pathogenesis resulting from this change in intracellular localization, with a particular focus on the role of the host. What emerges is that cytoplasmic access plays an important role in the pathophysiology of an increasing number of intracellular bacterial pathogens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available