Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 11, Pages 623-631Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.08.008
Keywords
avian influenza H7N9 viruses; transmission; pandemic potential
Categories
Funding
- National Institute of Allergy and Infectious Diseases Public Health Service research [RO1 AI080598, R56 AI099275]
- ERATO (Japan Science and Technology Agency)
- Strategic Basic Research Programs of the Japan Science and Technology Agency, Japan
- J-GRID (Japan Initiative for Global Research Network on Infectious Diseases)
- Grants-in-Aid for Scientific Research [25450422] Funding Source: KAKEN
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Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of 16 May 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential.
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