Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 2, Pages 100-106Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.11.006
Keywords
cryo-electron microscopy; flavivirus; togavirus; bio-threat agent; enveloped viruses; structures
Categories
Funding
- National Institute of Health [AI046420, GM071940]
Ask authors/readers for more resources
Class II viral fusion proteins are present on the envelope of flaviviruses and togaviruses, viruses that often cause tropical and subtropical diseases. These proteins use a second membrane protein as a molecular chaperone to assist their folding and to ensure proper function during viral assembly, maturation, and infection. Recent progress in structural studies of dengue viruses has revealed how the chaperone pre-membrane (prM), protein guides viral maturation and how pH is sensed in both the maturation and infection processes. Drastic conformation changes and reorganization of these viral membrane proteins occur during the transition from their metastable to stable structural states in a unidirectional, entropy-driven process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available