Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 9, Pages 498-507Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.06.004
Keywords
protein secretion; toxins; actin cross-linking; amidase; phospholipase
Categories
Funding
- Centre National de la Recherche Scientifique
- Aix-Marseille Universite
- Agence Nationale de la Recherche [ANR-10-JCJC-1303-03]
- Fondation pour la Recherche Medicale [FRM-SPF20101221116]
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The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into both prokaryotic and eukaryotic cells, therefore participating in interbacterial competition and virulence. The T6SS is functionally and structurally similar to the contractile bacteriophage cell puncturing device: the contraction of a sheath-like structure is believed to propel an inner tube terminated by a spike towards target cells, allowing the delivery of effectors. In this review, we summarize recent advances in the identification and characterization of T6SS effector proteins, highlighting the broad repertoire of enzymatic activities, and discuss recent findings relating to the secretion mechanisms.
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