Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 8, Pages 446-455Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.04.001
Keywords
influenza A virus; packaging; RNA-RNA interactions; supramolecular complex; genetic reassortment
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Funding
- Centre National de la Recherche Scientifique
- VirNext
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Influenza A viruses package their segmented RNA genome in a selective manner. Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics recently unveiled molecular details of this mechanism, whereby different influenza viral strains form different and unique networks of direct intermolecular RNA-RNA interactions. Together with detailed views of the three-dimensional structure of the viral ribonucleoparticles, these recent advances help us understand the rules that govern genome packaging. They also have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.
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