Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 12, Pages 676-685Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.09.002
Keywords
Staphylococcus; bacteremia; bloodstream infection; accessory gene regulator; quorum-sensing; antibiotic resistance
Categories
Funding
- Royal Society and Department of Medicine, Imperial College
- Department of Medicine PhD scholarship
- Imperial College PhD studentship
- Wellcome Trust - BBSRC
- Wellcome Trust [100958/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/I001492/1] Funding Source: UKRI
- MRC [MR/J006874/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I001492/1] Funding Source: researchfish
- Wellcome Trust [100958/Z/13/Z] Funding Source: researchfish
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Staphylococcus aureus is a major cause of bacteremia, which frequently results in serious secondary infections such as infective endocarditis, osteomyelitis, and septic arthritis. The ability of S. aureus to cause such a wide range of infections has been ascribed to its huge armoury of different virulence factors, many of which are under the control of the quorum-sensing accessory gene regulator (Agr) system. However, a significant fraction of S. aureus bacteremia cases are caused by agr-defective isolates, calling into question the role of Agr in invasive staphylococcal infections. This review draws on recent work to define the role of Agr during bacteremia and explain why the loss of this major virulence regulator is sometimes a price worth paying for S. aureus.
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