Journal
TRENDS IN MICROBIOLOGY
Volume 22, Issue 10, Pages 573-579Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.08.001
Keywords
Middle East; MERS-CoV; coronavirus; pathogenesis
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The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV infection.
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