Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 2, Pages 73-81Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.10.004
Keywords
pyocyanin; Pseudomonas; respiratory; redox; epithelium
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Funding
- NIH, National Institute of Allergy and Infectious Diseases [ZO1-AI-000614]
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Pseudomonas aeruginosa (PA) uses several virulence factors to establish chronic respiratory infections in bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis (CF) patients. One of its toxins, pyocyanin (PYO), is a redox-active pigment that is required for full virulence in animal models and has been detected in patients' airway secretions. PYO promotes virulence by interfering with several cellular functions in host cells including electron transport, cellular respiration, energy metabolism, gene expression, and innate immune mechanisms. This review summarizes recent advances in PYO biology with special attention to current views on its role in human airway infections and on its interactions with the first line of our airway defense, the respiratory epithelium.
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