Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 6, Pages 296-304Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.03.001
Keywords
high pressure thermal sterilization; endospore; germination and inactivation mechanisms; matrix interactions
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It is well known that spore germination and inactivation can be achieved within a broad temperature and pressure range. The existing literature, however, reports contradictory results concerning the effectiveness of different pressure-temperature combinations and the underlying inactivation mechanism(s). Much of the published kinetic data are prone to error as a result of unstable process conditions or an incomplete investigation of the entire inactivation pathway. Here, we review this field of research, and also discuss an inactivation mechanism of at least two steps and propose an inactivation model based on current data. Further, spore resistance properties and matrix interactions are linked to spore inactivation effectiveness.
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