Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 1, Pages 23-30Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.10.003
Keywords
cholera toxin; lysogenic phage; chromosome dimer resolution; tyrosine recombinases
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Integrative mobile genetic elements directly participate in the rapid response of bacteria to environmental challenges. They generally encode their own dedicated recombination machineries. CTX phi, a filamentous bacteriophage that harbors the genes encoding cholera toxin in Vibrio cholerae provided the first notable exception to this rule: it hijacks XerC and XerD, two chromosome-encoded tyrosine recombinases for lysogenic conversion. XerC and XerD are highly conserved in bacteria because of their role in the topological maintenance of circular chromosomes and, with the advent of high throughput sequencing, numerous other integrative mobile elements exploiting them have been discovered. Here, we review our understanding of the molecular mechanisms of integration of the different integrative mobile elements exploiting Xer (IMEXs) so far described.
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