Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 5, Pages 230-237Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.02.003
Keywords
bacterial competition; biofilm; cellular communication; contact-dependent growth inhibition; toxic nuclease; two-partner secretion proteins
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Funding
- National Science Foundation [0642052]
- National Institutes of Health [U54 AI065359, R21 AI099687, U01 GM102318, R01 GM078634]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1027546] Funding Source: National Science Foundation
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Bacteria cooperate to form multicellular communities and compete against one another for environmental resources. Here, we review recent advances in the understanding of bacterial competition mediated by contact-dependent growth inhibition (CDI) systems. Different CDI+ bacteria deploy a variety of toxins to inhibit neighboring cells and protect themselves from autoinhibition by producing specific immunity proteins. The genes encoding CDI toxin immunity protein pairs appear to be exchanged between cdi loci and are often associated with other toxin-delivery systems in diverse bacterial species. CDI also appears to facilitate cooperative behavior between kin, suggesting that these systems may have other roles beyond competition.
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