Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 8, Pages 380-388Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.06.001
Keywords
endocytosis; macropinocytosis; receptors; trans-infection; macrophage; dendritic cells
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Funding
- Ambizione grant from the Swiss National Science Foundation (SNF)
- SNF project [31003A_141222/1]
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Macrophages and dendritic cells (Des) are at the front line of defence against fungi, bacteria, and viruses. Together with physical barriers, such as mucus and a range of antimicrobial compounds, they constitute a major part of the intrinsic and innate immune systems. They have elaborate features, including pat-tern recognition receptors (PRRs) and specialized end ocytic mechanisms, cytokines and chemokines, and the ability to call on reserves. As masters of manipulation and counterattack, viruses shunt intrinsic and innate recognition, enter immune cells, and spread from these cells throughout an organism. Here, we review mechanisms by which viruses subvert endocytic and pathogen-sensing functions of macrophages and DCs, while highlighting possible strategic advantages of infecting cells normally tuned into pathogen destruction.
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