Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 12, Pages 652-659Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.09.009
Keywords
energy-coupling factor transporters; ATP-binding cassette transporters; substrate specificity; XRX motif; transport mechanism; ECF fold
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Funding
- Ministry of Science and Technology of China [2013CB127000]
- National Science Foundation of China [31370725, 31322016]
- Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences [2012OHTP, 2009CSP001]
- Shanghai Municipal Science and Technology Commission [11PJ1411300]
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Energy-coupling factor (ECF) transporters form a new family of ATP-binding cassette (ABC) transporters and are widely used by prokaryotes to take up micronutrients from the environment. Instead of using the periplasmic solute-binding proteins (SBPs), ECF transporters use the membrane S proteins for substrate capture and translocation. In this review, we will focus on structural advances that have been made regarding how substrates are recognized by ECF transporters and possible transport mechanisms employed by the ECF transporters.
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