Journal
TRENDS IN MICROBIOLOGY
Volume 21, Issue 11, Pages 602-612Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.09.004
Keywords
Helicobacter pylori; gastric cancer; autophagy; vacuolating cytotoxin (VacA)
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP 86619]
- Crohn's and Colitis Foundation of Canada (CCFC)
- CCFC-CIHR-Canadian Association of Gastroenterology fellowship
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Helicobacter pylori infection represents the strongest known risk factor for the development of gastric cancer. The vacuolating cytotoxin (VacA) plays a key role in disease pathogenesis by exerting pleiotrophic effects on the host. One effect of acute VacA exposure is the induction of autophagy. However, prolonged exposure to the toxin disrupts autophagy by preventing maturation of the autolysosome. Novel insights into the mechanism and consequences of this phenomenon have emerged, but many aspects remain largely unknown. Current evidence supports a scenario in which H. pylori-suppressed autophagy facilitates intracellular survival and persistence of the pathogen, while also generating an environment favoring carcinogenesis.
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