Journal
TRENDS IN MICROBIOLOGY
Volume 20, Issue 4, Pages 175-183Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.02.001
Keywords
stress granule; antiviral response; translation silencing; G3BP; TIA-1; eIF4G.PKR
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Funding
- NIAID NIH HHS [R01 AI050237, R01 AI050237-10] Funding Source: Medline
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Virus infection initiates a number of cellular stress responses that modulate gene regulation and compartmentalization of RNA. Viruses must control host gene expression and the localization of viral RNAs to be successful parasites. RNA granules such as stress granules and processing bodies (PBs) contain translationally silenced messenger ribonucleoproteins (mRNPs) and serve as extensions of translation regulation in cells, storing transiently repressed mRNAs. New reports show a growing number of virus families modulate RNA granule function to maximize replication efficiency. This review summarizes recent advances in understanding the relationship between viruses and mRNA stress granules in animal cells and will discuss important questions that remain in this emerging field.
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