Journal
TRENDS IN MICROBIOLOGY
Volume 20, Issue 8, Pages 376-384Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.05.001
Keywords
cell signaling; genetic circuits; logic gates; synthetic biology; cell programming
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Funding
- BBSRC (Biotechnology and Biological Sciences Research Council) [BB/G020434/1]
- BBSRC [BB/G020434/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G020434/1] Funding Source: researchfish
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Cells live in an ever-changing environment and continuously sense, process and react to environmental signals using their inherent signaling and gene regulatory networks. Recently, there have been great advances on rewiring the native cell signaling and gene networks to program cells to sense multiple noncognate signals and integrate them in a logical manner before initiating a desired response. Here, we summarize the current state-of-the-art of engineering synthetic genetic logic circuits to customize cellular signaling behaviors, and discuss their promising applications in biocomputing, environmental, biotechnological and biomedical areas as well as the remaining challenges in this growing field.
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