Journal
TRENDS IN MICROBIOLOGY
Volume 20, Issue 10, Pages 461-466Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.07.003
Keywords
regulation; Salmonella; infection; heterogeneity; bistability; bet-hedging
Categories
Funding
- NHGRI NIH HHS [P50 HG02360, P50 HG002360] Funding Source: Medline
- NIAID NIH HHS [U19 AI090882] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007270, T32 GM07270] Funding Source: Medline
Ask authors/readers for more resources
The spontaneous generation of distinct phenotypes within a clonal population of cells allows for both bet-hedging at the population level and the division of labor among subpopulations. This is emerging as an important theme in bacterial pathogenesis, because bacterial pathogens exhibit phenotypic heterogeneity with respect to characteristics that impact virulence. The phenomenon of persister cells and models of Salmonella enterica serovar Typhimurium (S. Typhimurium) pathogenesis illustrate the importance of non-genetic diversity in the disease process. Such heterogeneity can arise from specific genetic architectures amplifying stochastic fluctuations in factors affecting gene expression, and this also drives variation in eukaryotic cells. Thus reproducible variation in both host and pathogen processes affects the outcome of infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available