Journal
TRENDS IN MICROBIOLOGY
Volume 20, Issue 8, Pages 385-391Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.05.003
Keywords
human intestinal microbiota; plasticity; dietary habits; immune system; environment
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Traditionally regarded as stable through the entire lifespan, the intestinal microbiota has now emerged as an extremely plastic entity, capable of being reconfigured in response to different environmental factors. In a mutualistic context, these microbiome fluctuations allow the host to rapidly adjust its metabolic and immunologic performances in response to environmental changes. Several circumstances can disturb this homeostatic equilibrium, inducing the intestinal microbiota to shift from a mutualistic configuration to a disease-associated profile. A mechanistic comprehension of the dynamics involved in this process is needed to deal more rationally with the role of the human intestinal microbiota in health and disease.
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