Journal
TRENDS IN MICROBIOLOGY
Volume 19, Issue 8, Pages 419-426Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2011.04.005
Keywords
-
Categories
Funding
- Canadian Cystic Fibrosis Foundation (CCFF)
- Canadian Institutes for Health Research
Ask authors/readers for more resources
Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It demonstrates decreased susceptibility to most antibiotics due to low outer membrane permeability coupled to adaptive mechanisms and can readily achieve clinical resistance. Newer research, using mutant library screens, microarray technologies and mutation frequency analysis, has identified very large collections of genes (the resistome) that when mutated lead to resistance as well as new forms of adaptive resistance that can be triggered by antibiotics themselves, in in vivo growth conditions or complex adaptations such as biofilm growth or swarming motility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available