Journal
TRENDS IN MICROBIOLOGY
Volume 19, Issue 12, Pages 573-579Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2011.08.003
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Funding
- NIAID [R01AI43965, R01AI069321]
- Commonwealth of Kentucky Research Challenge Trust
- Israel Science Foundation, Israel Academy of Science and Humanities [306/6]
- USA-Israel Binational Science Foundation [2009418]
- National Institutes of Health [GM40602]
- Israeli Council for Higher Education
- Converging Technologies
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [2009418] Funding Source: National Science Foundation
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Post-translational lipidation by prenylation of the CaaX-box C-terminal motif in eukaryotic proteins facilitates anchoring of hydrophilic proteins, such as Ras and Rab, to membranes. A large cadre of bacterial effectors injected into host cells is anchored to host membranes by unknown mechanisms. As already documented for Legionella and Salmonella, we propose a common paradigm of microbial exploitation of the host prenylation machinery for anchoring of injected effectors to host membranes. This is supported by numerous potential microbial CaaX-box-containing proteins identified using refined bioinformatic tools. We also propose utilization of the CaaX motif as a membrane-targeting tag for proteins expressed in eukaryotic cells to facilitate deciphering of biological function.
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