Journal
TRENDS IN MICROBIOLOGY
Volume 19, Issue 2, Pages 95-103Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.11.005
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Funding
- Deutsche Forschungsgemeinschaft [SFB 638, TP A5, TRR-SFB83, TP 13, BA1505/2-2]
- ERC [233130]
- CNRS (Centre National de la Recherche Scientifique) [LO 1556/1-1]
- ANRS (Agence Nationale de Recherche sur le Sida)
- FINOVI (Foundation innovation en Infectiologie)
- FINOVI
- Region Rhone-Alpes
- European Research Council (ERC) [233130] Funding Source: European Research Council (ERC)
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A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.
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