Journal
TRENDS IN MICROBIOLOGY
Volume 19, Issue 7, Pages 323-329Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2011.05.003
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Funding
- National Science Foundation [0540879]
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- Natural Sciences and Engineering Research Council of Canada
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Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior.
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