Journal
TRENDS IN MICROBIOLOGY
Volume 18, Issue 5, Pages 205-214Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.02.003
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- Deutsche Forschungsgemeinschaft
- PSYSMO-ERANET
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In addition to the sugar phosphotransferase system (sugar PTS) dedicated to carbohydrate uptake, many Gram-negative bacteria possess a so-called nitrogen PTS (PTSNtr). Although fulfilling very different functions, both systems can communicate with each other by phosphate exchange. PTSNtr regulates diverse processes implicated in metabolism of nitrogen and carbon, and is essential for virulence in some bacteria. Additionally, it plays a role in potassium homeostasis by regulating the expression and activity of a high- and a low-affinity K+ transporter, respectively. In this article, we review recent advances in the understanding of the regulatory roles of PTSNtr in various organisms.
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