Journal
TRENDS IN MICROBIOLOGY
Volume 18, Issue 6, Pages 258-265Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.03.007
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Funding
- Alfred Osterlund Foundation
- Anna and Edwin Berger Foundation
- Marianne and Marcus Wallenberg Foundation
- Gyllenstierna Krapperup's Foundation
- Greta and Johan Kock Foundation
- Swedish Medical Research Council
- Cancer Foundation at the University Hospital in Malmo
- Research and Development Foundation of Skane County Council
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The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system.
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