Journal
TRENDS IN MICROBIOLOGY
Volume 18, Issue 6, Pages 248-257Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.04.001
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Funding
- DEO at Weill Medical College of Cornell University
- National Council for Scientific and Technological Development of the Ministry of Science and Technology of Brazil [200117/2008-4]
- Sao Paulo State University (UNESP)
- Sao Paulo Brazil
- National Cancer Institute of the National Institutes of Health
- Starr Cancer Consortium
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The nuclear factor (NF)-kappa B signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gamma-herpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappa B signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappa B modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.
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