Journal
TRENDS IN MICROBIOLOGY
Volume 18, Issue 12, Pages 561-568Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.09.002
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Funding
- Ministry of Education
- National Medical Research Council
- [T208A3105]
- [NMRC/1221/2009]
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Burkholderia pseudomallei is a highly versatile pathogen capable of infecting many species of animals and plants It is the causative agent of melioidosis, a medically important infectious disease in humans with a wide spectrum of disease manifestations Its versatility as a pathogen is reflected in its huge 7 2 Mb genome and the many virulence mechanisms it possesses, including three different type Ill secretion systems (T3SSs) Recent elucidation of the regulatory network of T3SS3 and the characterization of several T3SS proteins have enabled us to construct a model of the B pseudomallei T3SS3 apparatus and evaluate the role it plays in disease pathogenesis
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