Journal
TRENDS IN MICROBIOLOGY
Volume 17, Issue 4, Pages 139-145Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2009.01.004
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Funding
- INRA (French National Institute for Agronomical Research)
- MRC [G0700151] Funding Source: UKRI
- Medical Research Council [G0700151] Funding Source: researchfish
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Extracellular proteins are a subject of intense interest because of their essential roles in bacterial lifestyles. However, several terms related to secretion are used confusingly in the literature, and this is a topical issue in genomics and proteomics. Defining a secreted protein as actively translocated via a secretion system, here, we put into perspective that homologous translocation systems can result in radically different subcellular localizations of a secreted protein. We propose using standardized nomenclature for secretion systems from type I to type Vill for Gram-negative bacteria only, whereas the terms 'Sec' (secretion), 'Tat' (twin-arginine translocation), 'FEA' (flagella export apparatus), 'FPE' (fimbrilin-protein exporter), 'holin' (hole forming) and 'Wss' (WXG100 secretion system) should be applied to translocation systems across the cytoplasmic membrane of both Gram-positive and Gram-negative bacteria. Finally, we discuss why the term 'exoproteome' should be favoured over 'secretome' when describing the subset of proteins present in the extracellular milieu.
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