Journal
TRENDS IN MICROBIOLOGY
Volume 17, Issue 1, Pages 13-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.10.001
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Funding
- Biotechnology and Biological Sciences Research Council [F009224/1, F009429/1, EGH16082]
- the Medical Research Council (MRC)
- the Commission of the European Community [LSHG-CT-2004-005257]
- The Royal Society
- T.P. is ark AIRC Senior Non-Clinical Research Fellow
- M.I.H. is a Research Councils UK Academic Fellow
- Biotechnology and Biological Sciences Research Council [BB/F009429/1] Funding Source: researchfish
- Medical Research Council [G117/519] Funding Source: researchfish
- BBSRC [BB/F009429/1] Funding Source: UKRI
- MRC [G117/519] Funding Source: UKRI
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Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.
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