Journal
TRENDS IN MICROBIOLOGY
Volume 16, Issue 1, Pages 33-40Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2007.10.010
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI061381, R01AI061381] Funding Source: NIH RePORTER
- NIAID NIH HHS [R56 AI061381, R01 AI061381-03, R01 AI061381, AI061381] Funding Source: Medline
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Various cell-surface multisubunit protein polymers, known as pill or fimbriae, have a pivotal role in the colonization of specific host tissues by many pathogenic bacteria. In contrast to Gram-negative bacteria, Grampositive bacteria assemble pill by a distinct mechanism involving a transpeptidase called sortase. Sortase crosslinks individual pilin monomers and ultimately joins the resulting covalent polymer to the cell-wall peptidoglycan. Here we review current knowledge of this mechanism and the roles of Gram-positive pill in the colonization of specific host tissues, modulation of host immune responses and the development of bacterial biofilms.
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