Journal
TRENDS IN MICROBIOLOGY
Volume 16, Issue 7, Pages 318-325Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.04.002
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Funding
- NIAID NIH HHS [K08 AI-064564, K08 AI064564-01A2, K08 AI064564] Funding Source: Medline
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Historically, the study of bacterial catabolism of complex carbohydrates has contributed to understanding basic bacterial physiology. Recently, however, genome-wide screens of streptococcal pathogenesis have identified genes encoding proteins involved in complex carbohydrate catabolism as participating in pathogen infectivity. Subsequent studies have focused on specific mechanisms by which carbohydrate utilization proteins might contribute to the ability of streptococci to colonize and infect the host. Moreover, transcriptome and biochemical analyses have uncovered novel regulatory pathways by which streptococci link environmental carbohydrate availability to virulence factor production. Herein we review new insights into the role of complex carbohydrates in streptococcal host-pathogen interaction.
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